mBER
Structure-guided VHH nanobody binder design
mBER is an open-source binder design pipeline that conditions AlphaFold-Multimer with sequence and structure templates to design antibody-format binders, validated with million-scale experimental screening. It takes antigen targets and templates as input. Returns binder sequences and models ranked for expression and affinity screening.
mBER is being onboarded — request access and be first in line.
At a glance
- Input
- Antigen structure with epitope (PDB)
- Output
- Nanobody designs (PDB)
- Developed by
- Manifold Bio
- Published
- Manifold Bio, 2025 · 2025
#nanobodies#binder-design#vhh
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