Molecular render representing AntiFold

AntiFold

Antibody sequence design from structure

AntiFold is an antibody-specific inverse folding model that designs CDR sequences to fold onto a given antibody backbone, trained on paired antibody structure data. It scores and proposes sequences with higher developability than generic models. Used to humanize, affinity-mature and redesign antibodies in silico.

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At a glance

Input
Antibody backbone (PDB)
Output
Designed CDR sequences (FASTA)
Developed by
Technical University of Denmark
Published
Olsen et al., 2022 · 2022
#inverse-folding#cdr-design#sequence-design