IgFold
Fast antibody structure prediction without MSAs
IgFold predicts antibody Fv structures in seconds directly from heavy- and light-chain sequences using a pretrained protein language model without MSAs. Accuracy approaches experimental structures on standardized benchmarks. Provides rapid template models for docking, redesign and developability assessment of antibody panels.
IgFold is being onboarded — request access and be first in line.
At a glance
- Input
- Heavy and light sequences (FASTA)
- Output
- Antibody Fv structure (PDB)
- Developed by
- Johns Hopkins University
- Published
- Ruffolo et al., Nature Methods 2023 · 2022
#antibody-design#msa-free#structure-prediction
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