Humatch

Humanize antibodies with optimal V-gene matching

Humatch performs fast, gene-specific humanization of paired antibody heavy and light chains using convolutional networks trained on human repertoire data. It classifies germline genes and applies mutations jointly across chains to maintain VH/VL pairing. Optimizes humanness while preserving stability and expression potential.

Humatch is being onboarded — request access and be first in line.