BioPhi
Antibody humanization with humanness scoring
BioPhi is an antibody humanization and humanness-scoring platform combining the Sapiens language model for sequence humanization and OASis for humanness percentile scoring. Given a non-human antibody sequence, it proposes humanized variants ranked by humanness and liability metrics. Retains specificity while reducing immunogenicity risk.
BioPhi is being onboarded — request access and be first in line.
At a glance
- Input
- Antibody sequence (FASTA)
- Output
- Humanized sequences (FASTA)
- Developed by
- ETH Zurich
- Published
- Prihoda et al., MAbs 2022 · 2022
#humanization#language-model#developability
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