SolubleMPNN
Solubility-biased sequence design for expressible proteins
SolubleMPNN is a ProteinMPNN variant trained without membrane proteins, steering designed sequences away from hydrophobic surfaces and toward soluble expression. The practical choice when designs must purify and stay soluble — enzymes, binders and scaffolds headed for the bench. Same backbone input and constraints as ProteinMPNN, with solubility built into the prior.
SolubleMPNN is live on MolPilot — load a structure, mark what to redesign, and press Design.
At a glance
- Input
- Protein backbone (PDB)
- Output
- Soluble-biased designed sequences (FASTA)
- Developed by
- Baker Lab, UW
- Published
- Dauparas et al., 2023 · 2023
#sequence-design#solubility#inverse-folding
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