RFdiffusion3

All-atom diffusion with non-protein interaction conditioning

RFdiffusion3 extends backbone diffusion to all-atom protein design with explicit conditioning on ligands, nucleic acids, metals and modified residues. It generates binders and enzymes around non-protein partners directly at atomic detail. Reduces the need for post-hoc redocking in complex design campaigns.

RFdiffusion3 is being onboarded — request access and be first in line.