Molecular render representing ODesign

ODesign

All-atom binder design with controlled interaction modes

ODesign is an all-atom generative world model that designs binders and complexes with explicit control over interaction modes, target sites and chain lengths. It supports protein, nucleic acid and small-molecule components in one framework. Enables programming biomolecular interactions rather than only predicting them.

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At a glance

Input
Target structure with epitope (PDB)
Output
Binder designs (PDB)
Developed by
University of Washington
Published
Zhang et al., arXiv 2025 · 2025
#binder-design#all-atom#interaction-modes