EvoDiff
Generative sequence design and motif scaffolding
EvoDiff applies discrete diffusion to protein sequences to generate diverse, soluble proteins and functional motifs within larger scaffolds. It operates purely in sequence space, so designs require no backbone input and can be validated directly by structure predictors. Includes models for unconditional generation and motif scaffolding.
EvoDiff is being onboarded — request access and be first in line.
At a glance
- Input
- Motif or length spec (FASTA)
- Output
- Designed sequences (FASTA)
- Developed by
- Microsoft Research
- Published
- Alamdari et al., 2023 · 2023
#diffusion#sequence-design#motif-scaffolding
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