BoltzGen
High-affinity binders via all-atom diffusion
BoltzGen designs binders across formats, including proteins, peptides and nanobodies, against protein or small-molecule targets using all-atom diffusion with built-in structural reasoning about target-binder interactions. Generation integrates confidence scoring for candidate triage. Outputs full designed complexes ready for structure-based filtering.
BoltzGen is being onboarded — request access and be first in line.
At a glance
- Input
- Target structure (PDB)
- Output
- Binder complexes (PDB)
- Developed by
- MIT
- Published
- Stark et al., bioRxiv 2025 · 2025
#binder-design#diffusion#all-atom
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