PopularProtein Design & Engineering
BindCraft
One-shot design of functional protein binders
BindCraft couples RFdiffusion backbone generation, ProteinMPNN sequence design and AlphaFold-based filtering in a push-button pipeline that yields high-affinity binders in a single run. Inputs are a target structure and optional epitope constraints. It has produced experimentally validated nanomolar binders without experimental screening.
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At a glance
- Input
- Target structure (PDB)
- Output
- Binder sequences and models (PDB)
- Developed by
- EPFL
- Published
- Pacesa et al., 2024 · 2024
#binder-design#pipeline#de-novo
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