OpenFold3
Open-source AlphaFold3 reproduction at near parity
OpenFold3 reproduces the AlphaFold3 biomolecular co-folding system as fully open-source code with released training data and procedures. It predicts protein complexes with nucleic acids, ligands and modifications at accuracy close to the original. A reference implementation for academic groups needing transparent, modifiable complex prediction.
OpenFold3 is live on MolPilot — paste a sequence and press Fold.
At a glance
- Input
- Sequences and ligands (FASTA, SDF)
- Output
- All-atom complex (mmCIF)
- Developed by
- OpenFold Consortium
- Published
- OpenFold Consortium, 2025 · 2025
#open-source#co-folding#reproduction
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