OpenDDE
Independent 655M-parameter open model in the AlphaFold3 family
OpenDDE is an independent open-source reimplementation of the AlphaFold3 architecture published by Aureka Research under Apache 2.0. It folds proteins together with ligands, nucleic acids and modified residues through a two-stage trunk and diffusion decoder. Its 655.8M-parameter checkpoint is one of the largest fully open models in this family.
OpenDDE is live on MolPilot — paste a sequence and press Fold.
At a glance
- Input
- Sequences and ligands (FASTA, SDF)
- Output
- All-atom complex (PDB)
- Developed by
- Aureka Research
- Published
- Aureka Research, 2025 · 2025
#open-source#co-folding#all-atom
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