MUSCLE5
High-accuracy alignment with PPP refinement
MUSCLE5 constructs high-accuracy multiple sequence alignments using ensemble partitioning and profile-profile alignment refinement, including PPP trees for large inputs. It improves accuracy over earlier MUSCLE versions on benchmark sets. Practical for alignment-critical tasks such as phylogenetics and homology modeling.
MUSCLE5 is live on MolPilot — paste a sequence and press Fold.
At a glance
- Input
- Sequences (FASTA)
- Output
- Multiple sequence alignment (FASTA)
- Developed by
- drive5 (Robert Edgar)
- Published
- Edgar, 2022 · 2022
#alignment#msa#high-accuracy
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