Foldseek
Search structures by 3D similarity across AlphaFold DB
Foldseek searches protein structure databases by encoding backbones as 3D-interaction alphabet sequences, enabling alignment-speed searches over AlphaFold DB and PDB. It detects remote homologs invisible to sequence search. Powers structure-based annotation, clustering and distant-relationship discovery at scale.
Foldseek is being onboarded — request access and be first in line.
At a glance
- Input
- Structures (PDB, CIF)
- Output
- Structure matches (BLAST-like)
- Developed by
- Seoul National University
- Published
- van Kempen et al., Nature Biotechnology 2023 · 2023
#structure-search#remote-homology#alignment
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