ESMFold2-Fast
All-atom folding for proteins, nucleic acids and ligands
ESMFold2 extends language-model folding to all-atom biomolecular complexes, covering proteins, DNA, RNA, ligands and modifications without MSAs. A single-sequence input is enough to produce docked complexes in seconds. Suited to interactome-scale modeling where generating MSAs for every pair is infeasible.
ESMFold2-Fast is live on MolPilot — paste a sequence and press Fold.
At a glance
- Input
- Sequences and ligands (FASTA, SDF)
- Output
- All-atom complex (PDB)
- Developed by
- Chan Zuckerberg Biohub
- Published
- Candido et al., 2025 · 2025
#msa-free#all-atom#complexes
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