Molecular render representing DeepEMhancer

DeepEMhancer

Sharpen and denoise cryo-EM maps with deep learning

DeepEMhancer post-processes cryo-EM density maps using a trained convolutional network that sharpens flexible regions while denoising background, mimicking expert map manipulation. It takes input maps and produces enhanced densities for model building. Improves interpretability of marginal-resolution regions.

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At a glance

Input
Cryo-EM map (MRC, CCP4)
Output
Sharpened map (MRC)
Developed by
CNB-CSIC, Madrid
Published
Sanchez-Garcia et al., Communications Biology 2021 · 2020
#cryo-em#map-sharpening#post-processing